www.kumc.edu

www.kumc.edu

FALL FACULTY ASSEMBLY MEETING November 14, 2017 Frontiers: University of Kansas Clinical and Translational Science Institute KU CTSI OUR THREE SIMPLE GOALS: 1. Support researchers 2. Train researchers 3. Grow the research enterprise THE WIDER CONTEXT KUMC investigators submitted $547m in new grants KUMC was awarded $105m KUMC expended $120m New and Renewed Infrastructure Grants: Alzheimers Disease Center Cancer Center KIDDRC (KS Intellectual and Developmental Disabilities Research Center)

COBRE (Center of Biomedical Research Excellence; 2 awards) Frontiers FRONTIERS: University of Kansas Clinical and Translational Institute (KU CTSI) KUMC was awarded $25m over 5 years Year 1 runs September 7, 2017 June 30, 2018 Principal Investigator: Richard Barohn Associate Directors: Kim Kimminau & William Brooks Administrative Director: Jen Baker Assistant Administrative Director: Robin Liston FRONTIERS ASPIRATIONS BETTER RESOURCES FOR INVESTIGATORS EXPANDED NAVIGATORS PROGRAM Navigators assist investigators with ALL aspects of conducting human translational research PROMOTE LINKAGES THROUGH TEAM SCIENCE Collaborations that cross disciplines and leverage the regions and states institutions EDUCATION

Educating the current and next generation of clinical and translational researchers NIH Awards KUMC was awarded $105m in new awards More than $30m than last year New awards for FY 16 = $73m Have over 700 clinical trials and brought in $15m in revenue - Up $900K NIH Awards by category for FY17 RO1 RO1 Supplements RO3 R56 R21 P30 P30 Supplements KO1 K23 F31 F32 R13

U Awards S Equipment Grant 20 5 1 1 8 2 1 2 1 1 2 2 2 1 2017 Frontiers Stimulus Awardees

Ongoing funded projects $10K 20K each NIH Prior Approval Spend by 6/30/18 SOM - Crystal Lumpkins, Tribal and Urban Health Communication Investigating how American Indian Leaders and Elders throughout the Midwest Perceive Themselves as Health Promoters SON - Janet Pierce, Reducing Symptom Burden in Patients with Heart Failure with Preserved Ejection Fraction Using Ubiquinol and/or D-Ribose SHP - Neena Sharma, Opioid and Rehabilitation Following Lumbar Spine Surgery SHP - Catherine Siengsukon, Cognitive Behavioral Therapy for Insomnia to Address Insomnia Symptoms in People with Multiple Sclerosis KU Wichita - Matt Macaluso, Augmentation versus Switch: Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders with Treatment Resistant Depression CMH - Melissa Miller, Enhanced Intervention to Improve Adolescent Outcomes: A Clinical Trial CMH - Jennifer Shuster, Evaluation of Neuraminidase Antibodies in Pediatric Stem Cell Transplant Patients Receiving High versus Standard Dose Influenza Vaccine St. Lukes - John Spertus, The Impact of i2b2 on Evaluation of the Primary Care Centered Lung Cancer Screening Protocol Using an Epic Application CMH/UMKC - Tamorah Lewis/Paula Nichols, Single Nucleotide Polymorphisms (SNPs) in Genes Responsible for Steroid Metabolism and Response in Preterm Infants with Bronchopulmonary Dysplasia Organization of

Frontiers Resources FRONTIERS CORES TRAINING CORE TL1 CAREER DEVELOPMEN T CORE KL2 INFORMATICS COMMUNITY AND COLLABORATI ON TRANSLATION AL ENDEAVORS ADMINISTRATI ON

INSTITUTE FOR ADVANCING MEDICAL INNOVATION RESEARCH METHODS NETWORK CAPACITY HUB RESEARCH CAPACITY FRONTIERS CORES CORE LEADERSHIP NAVIGATOR Informatics

Waitman Informatics: McMahon Clinical Informatics: Wennberg Community & Collaboration Greiner Team Science: Murray Community/ISP: TBN Translational Endeavors Spertus / Smith Implementation: TBN Entrepreneurship: Nagel/Meyer Research Methods Mayo Caldwell/Blackwell

Statistics: Tremblay RKS: Hindle Hub Research Capacity Berkley-Patton/Maliski Clements/Burns Community/ISP: TBN PCI Navigator: Lahner Network Capacity Kluding / Blackwell IRB/Reliance: Griffith Recruitment/RTIU: Murray IAMI Weir / Leeder Schorno

KL2 Ellerbeck / Spertus Kerling TL1 Choi / Leeder Kerling FRONTIERS CORES INFORMATICS Waitman HERON Support regional access to resource Research in clinical workflow Conduct deep phenotyping

ADMINISTRATI ON Improve education, research quality and compliance Through secure data management, streamlining and effective tools for collaboration FRONTIERS CORES COMMUNITY AND COLLABORATION Greiner Kimminau/Brooks Berkley-Patton/ Maliski ADMINISTRATI ON Community and Special Population Support linkages to recruitment sites, community organization

partners, instruction in bootcamp methods, translation services Team Science Schedule and coordinate brainstorming sessions Collision Mixers Improve exposure and education regarding reaching vulnerable and underrepresented participants FRONTIERS CORES Implementation Science Entrepreneurship ADMINISTRATI ON TRANSLATIO NAL ENDEAVORS Spertus / Smith

Training Center Hub for training available through K & T programs, research methods/RKS, informatics, community, team science and IAMI Pilot Awards Stimulus Grants Trailblazer Awards Dr. Lauren Aaronson BERD Special Populations IAMI Entrepreneurship Consortium Pilot Awards FRONTIERS CORES Ensure optimal study design Encourage use of novel statistical methods Educate/train investigators and staff in biostatistics and regulatory requirements

ADMINISTRATI ON RESEARCH METHODS Mayo Caldwell Support for protocol, consent, IND/IDE, adverse event reporting, safety and regulatory management, compliance, IP Research and Discovery Grand Rounds Clinical Research Coordinator Bootcamp Research Personnel Networking GCP and RCR training FRONTIERS CORES ADMINISTRATIO N HUB RESEARCH CAPACITY Berkley-Patton /

Maliski Clements / Burns Engage special populations in translational research ISP Workgroup Close collaboration with Community and Recruitment experts Diversity Trailblazer Awards Foundation and support to conduct human subjects research CTSU FRONTIERS CORES ADMINISTRATI ON NETWORK

CAPACITY Kluding Blackwell Multi-site trial facilitation Start-up Single IRB Contracts and budgeting Project management support Speed trial completion with effective recruitment/retention resources and expertise Connect to NCATS Trial Innovation Network FRONTIERS CORES Product development Methods Lifespan focused ADMINISTRATI ON

INSTITUTE FOR ADVANCING MEDICAL INNOVATION Weir / Leeder Collaborate with local, regional and national partners to develop/demonstrate Drug development Diagnostic technologies Medical device technologies Mentorship FRONTIERS CORES CAREER DEVELOPMEN T CORE -KL2 Ellerbeck / Spertus

Support junior scientists Mentors Tools Experiences MSCR degree ADMINISTRATI ON Encourage recruitment of diverse pool Evaluate to drive continuous improvement FRONTIERS CORES Foster career development Interdisciplinary teams Mentors Training TRAINING CORE -TL1 Choi / Leeder

ADMINISTRATI ON Recruit highly promising and diverse pool of pre-doctoral and post-doctoral trainees Evaluate effectiveness FRONTIERS CORES TRAINING CORE TL1 CAREER DEVELOPMEN T CORE KL2 INFORMATICS COMMUNITY

AND COLLABORATI ON TRANSLATION AL ENDEAVORS ADMINISTRATI ON INSTITUTE FOR ADVANCING MEDICAL INNOVATION RESEARCH METHODS NETWORK CAPACITY HUB RESEARCH CAPACITY

Questions? Contact the Frontiers Office for assistance 913-588-6290

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