Virus - LACOE

Virus - LACOE

Virus What am I? Virus What am I? Virus What am I?

Virus What am I? Virus What am I? Virus How do I spread?

Virus How do I spread? Virus How do I spread? Virus How do I spread?

Virus How do I spread? Virus What is my relationship between human behavior and me? Virus What is my relationship between

human behavior and me? Virus What is my relationship between human behavior and me? Virus What is my relationship between human behavior and me?

Virus What is my relationship between human behavior and me? Virus What is my relationship between human behavior and me?

Virus What is my relationship between human behavior and me? What do you know about viruses? Think Pair

About the questions Share Talk to your partner Share with the class

about the answers. What is a virus? How do I spread? What is my relationship between human behavior and me? Video Identify three new ideas about viruses http://

209.68.130.2/videos/qt/300k/1_3161_ 300k.mov New Questions you need answered. As you read, open to address below and add your questions to Web Response http://PollEv.com Or

Add your questions to post it notes. QAR Strategy Right There: What is vomito Negro? Think and Search: What is the pattern of the viruss effect on the body?

Author and you: How does Monets experience in the emergency room relate to your own experiences in an emergency room or some other time when you needed swift attention? On Your Own: If you were seated next to a passenger with these symptoms, what would you do?

E.coli and T4 phage Virusbook Taking advantage of our social network Waiting for a flight Procedures

You must wear goggles at all times. Day 1: Find a person from a different table. 1. Ask each other a question about the story. 2. Exchange 1 ml of water, if they did not know the answer, and of ml of water if they did know the answer. 3. Find another person and ask another question. 4. Return to your desks and write down the names of

the people you met. Procedures You must wear goggles at all times. Day 2: Find a person from a different table. 1. Ask each other a question about the story. 2. Exchange 1 ml of water, if they did not know the answer, and of ml of water if they did know the

answer. 3. Find another person and ask another question. 4. Return to your desks and write down the names of the people you met. Infection Did you contract the virus One person in the Waiting room had the

filovirus. Who had it? Did you have contact with that person? Did you have contact with that person indirectly? How can we be sure who has the virus? Classify the questions Right There

Think and Search Author and You On Your Own Search Pg 37-38; 62-67; 83-86; 98-100; 105-109;

117-118; 197-198 http://www.cdc.gov/ncidod/dvrd/spb/mnpag es/dispages/ebola.htm http://www.biology.arizona.edu/cell_bio/tut orials/pev/page4.html 82-84; 121-129; 153-157; 174-178; 185-192; 204-206; 323-325 Science @ Home

Email me tonight your answers [email protected] 1. What is a virus? 2. How do they spread? 3. How does human behavior affect the spread of viruses. 4. one question from the Classify QAR Read 215-17 & 360-371

Right There What other ways can filovirus spread? As you read Develop questions: Think and Search Author and you On Your Own

Read 350-354 & 567-584 EBOLA POSTER You will make a Ebola virus prevention poster. It must include. Very few words, Pictures showing how to prevent the spread of the virus.

It should not scare people, but be informative. Structure 20 nm Genomes Ds DNA (Papo, adeno, herpes, pox) Ss DNA (Parvo) Ds RNA (reovirus)

Ss+ RNA (pico and toga) SS- RNA (Rhabdo,Paramyxo, Ortho) Retrorivus ss RNA Structure Capsids Protein coats Phages

Structure Some viruses have structures have membranous envelopes that help them infect hosts These viral envelopes surround the capsids of influenza viruses and many other viruses found in animals Viral envelopes, which are derived from the host cells membrane, contain a combination of viral and host cell molecules

LE 18-4c Membranous envelope Capsid RNA Glycoprotein

80200 nm (diameter) 50 nm Influenza viruses Bacteriophages, also called phages, are viruses that infect bacteria They have the most complex capsids found among viruses

Phages have an elongated capsid head that encloses their DNA A protein tailpiece attaches the phage to the host and injects the phage DNA inside LE 18-4d Head Tail

sheath Tail fiber DNA 80 225 nm 50 nm

Bacteriophage T4 LE 18-5 Entry into cell and uncoating of DNA VIRUS DNA

Capsid Transcription Replication HOST CELL Viral DNA mRNA Viral DNA

Capsid proteins Self-assembly of new virus particles and their exit from cell Reproduction

Class/Family Envelope Examples/Disease I. Double-stranded DNA (dsDNA) Adenovirus No Papovavirus No Respiratory diseases, animal tumors Papillomavirus (warts, cervical

cancer): polyomavirus (animal tumors) Herpesvirus Yes Herpes simplex I and II (cold sores, genital sores); varicella zoster (shingles, chicken pox); Epstein-Barr virus

(mononucleosis, Burkitts lymphoma) Poxvirus Smallpox virus, cowpox virus Yes

Class/Family Envelope Examples/Disease II. Single-stranded DNA (ssDNA) Parvovirus No B19 parvovirus (mild rash) III. Double-stranded RNA (dsRNA)

Reovirus No Rotavirus (diarrhea), Colorado tick fever virus Class/Family Envelope

Examples/Disease IV. Single-stranded RNA (ssRNA); serves as mRNA Picornavirus No Rhinovirus (common cold); poliovirus, hepatitis A virus,

and other enteric (intestinal) viruses Coronavirus Yes Flavivirus

Yes Togavirus Yes Severe acute respiratory syndrome (SARS) Yellow fever virus, West Nile

virus, hepatitis C virus Rubella virus, equine encephalitis viruses Class/Family Envelope Examples/Disease V. ssRNA; template for mRNA synthesis

Filovirus Yes Ebola virus (hemorrhagic fever) Orthomyxovirus Yes Influenza virus

Paramyxovirus Yes Measles virus; mumps virus Rhabdovirus

Yes Rabies virus VI. ssRNA; template for DNA synthesis Retrovirus Yes

HIV (AIDS); RNA tumor viruses (leukemia) Other Issues

HIV and AIDS Viruses and Cancer Vaccines Plant Viruses Whats New LE 18-9

Glycoprotein Viral envelope Capsid Reverse transcriptase RNA

(two identical strands) The viral DNA that is integrated into the host genome is called a provirus Unlike a prophage, a provirus remains a permanent resident of the host cell The hosts RNA polymerase transcribes the proviral DNA into RNA molecules

The RNA molecules function both as mRNA for synthesis of viral proteins and as genomes for new virus particles released from the cell LE 18-10 HIV Membrane of white blood cell

HOST CELL Reverse transcription Viral RNA 0.25 m

HIV entering a cell RNA-DNA hybrid DNA NUCLEUS Chromosomal DNA

RNA genome for the next viral generation New HIV leaving a cell mRNA

Provirus Viral Diseases in Plants More than 2,000 types of viral diseases of plants are known Some symptoms are spots on leaves and fruits, stunted growth, and damaged flowers or roots

Plant viruses spread disease in two major modes: Horizontal transmission, entering through damaged cell walls Vertical transmission, inheriting the virus from a parent Viroids and Prions: The Simplest Infectious Agents

Viroids are circular RNA molecules that infect plants and disrupt their growth Prions are slow-acting, virtually indestructible infectious proteins that cause brain diseases in mammals Prions propagate by converting normal proteins into the prion version Normal prion protein are water soluble. Prions not water soluble.

CJD and Mad cow Diseases LE 18-13 Prion Original prion

Many prions Normal protein New prion Evolution Evolution of viruses

After first cells Fragments of cellular nucleic acids Similar genomes to hosts oncoviruses Plasmids or Transposons Selfreplicating genetic material in bacteria and fungi Whats new? Prions can evolve: Scripps

Research Institute in 2010 Each time the protein replicates theyre minor changes and errors. Any changes in the environment results in the best suited shapes multiplying faster. Whats new?

Prions found in Yeast and are a part of epigenetics MIT 2011 Yeast prions affect RNA transcription that causes changes in the protein. Found in 255 of the 700 different species of yeast. May only be a yeast issue.

Whats new with viruses 8% of our DNA sequence has viral genomes 2000 Syncytin a viral protein part of the evolution of placental mammals. This protein fuses cells together; required in development of the placenta and fetus

The Story of Syncytin grows Chimps gorillas and primates all have the same protein. found syncytin 1 and 2 part of pre-eclampsia Dangerous high blood pressure if synctin 1 or 2 not working. Syncytin 2 slows mothers immunes system down so it does not attack the fetus.

2005 found syncytin in mice, and it is required for survival of the fetus. Mouse and primate syncytin different sequences, different virus. The Story of Syncytin grows Rabbits have an additional different syncytin sequence. This sequence not in their closely related

cousins: the Pika. Conclusion: new Syncytin infected rabbits 30mya. The Story of Syncytin grows Syncytin in Carnivores

Recently Viewed Presentations

  • International Telecommunication Union

    International Telecommunication Union

    ITU Workshop on "ICT Security Standardization for Developing Countries" (Geneva, Switzerland, 15-16 September 2014) Step-up authentication a key enabler of mobile on-line trust
  • Forest-Based Sector Technology Platform

    Forest-Based Sector Technology Platform

    Forest-Based Sector Technology Platform For the 7th R&D Framework Programme, EU Commision has created a new tool, Technology Platform, characterised by Shared vision Long-term perspective (2030) Major challenges Key deliverables of a Technology Platform Vision document (stage 1) Shared Vision...
  • Excel Lesson 2 Formatting and Editing Worksheets

    Excel Lesson 2 Formatting and Editing Worksheets

    The Font group on the Home tab on the Ribbon includes options for selecting fonts, font size, underline, and font color. Formatting Cells (continued) ... Copy, and Paste buttons are located in the Clipboard group on the Home tab. ......
  • Python Mapper: http://danifold.net/mapper/ See also mappersummary2a.pdf - A

    Python Mapper: http://danifold.net/mapper/ See also mappersummary2a.pdf - A

    5 4. 3. mapper.filters.kNN_distance(data, k, metricpar={}, callback=None) The distance to the k-th nearest neighbor as an (inverse) measure of density.
  • The Home Front during WWI - lcboe.net

    The Home Front during WWI - lcboe.net

    The Home Front during WWI ... 1919 70,000 War industries work Enlistment in segregated units Opportunities for African Americans during WWI · The War Industries Board told factories what to produce and the War Labor Board settled labor disputes Labor...
  • Pollution - mrgaydos.weebly.com

    Pollution - mrgaydos.weebly.com

    Pollution By: Tom and Emily Gorham What is pollution? CFC's Global warming Acid rain Smoking Littering Pollution It is the undesirable state of the natural environment being contaminated by harmful substances The harmful substances is known as pollutant Can you...
  • Hands-On Ethical Hacking and Network Security

    Hands-On Ethical Hacking and Network Security

    Hands-On Ethical Hacking and Network Defense ... ettercap Common Internet File System (CIFS) CIFS replaced SMB for Windows 2000, XP, and Windows 2003 Server SMB is still used for backward compatibility CIFS is a remote file system protocol Enables computers...
  • Καλλιέργειες

    Καλλιέργειες

    Καλλιέργειες Ανάπτυξη βακτηριακών καλλιεργειών Bακτηριακή διαίρεση (απλή διχοτόμηση) Χρόνος γενεάς (χρόνος που απαιτείται για να διαιρεθεί ένα κύτταρο, χρόνος διπλασιασμού του πληθυσμού κυττάρων) Λογαριθμική ...