Management of UC

Management of UC

Management of UC Background: Ulcerative Colitis (UC)

Impact of UC on Patients' Lives

Unmet Needs in UC: Expert Group Consensus

Unmet Needs in UC: Expert Group Consensus (cont)

Treatment Options for UC Efficacy of Anti-TNF Therapy in UC

VARSITY: First Head-to-Head Superiority Trial Comparing 2

Biologics in UC VARSITY: Efficacy and Safety of

Vedolizumab in UC

VARSITY: Clinical Response Over Time

Use of Histology in UC VARSITY: Vedolizumab Improves

Histologic Healing OCTAVE 1 and 2: Tofacitinib Induction

Significantly Improves Symptoms vs Placebo

Safety of Current Therapies for UC UNIFI: Ustekinumab in Moderate to

Severe UC UNIFI: Select Baseline

Characteristics UNIFI: Efficacy of Ustekinumab

Induction UNIFI: Ustekinumab in Moderate to

Severe UC UNIFI: Efficacy of Ustekinumab

Maintenance UNIFI: Safety of Ustekinumab

Rationale for Targeting IL-23 in UC

Phase 3 Trials of IL-23 Inhibitors in UC

JAK Inhibitors in Development in IBD Factors that Influence Treatment

Decisions in Moderate to Severe UC Which Tools Do You Use to Switch

Therapies? Involving Patients in Treatment

Decisions Concluding Remarks

Abbreviations

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