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Main Title Slide — Always use Title Case on Slide Titles

Targeted Intraoperative Radiotherapy versus Whole Breast Radiotherapy for Breast Cancer (TARGIT-A Trial): An International, Prospective, Randomised, Non-Inferiority Phase 3 Trial Baum M et al. Proc ASCO 2010;Abstract LBA517. Vaidya JS et al. Lancet 2010;[Epub ahead of print]. Introduction Local recurrence after breast-conserving surgery is located in the index quadrant 90% of the time. Restriction of radiation therapy to immediate area surrounding the tumor bed following removal of primary tumor may be adequate (Br J Cancer 1996;74:820). External beam radiation therapy (EBRT) is a safe and effective treatment. Side effect risk is low but schedule can be inconvenient and is often untenable for elderly women.

Current study objective: Evaluate the approach of substituting targeted intraoperative radiotherapy (TARGIT) for the conventional policy of whole breast EBRT in selected patients with early breast cancer. Baum M et al. Proc ASCO 2010;Abstract LBA517; Vaidya JS et al. Lancet 2010;[Epub ahead of print]. Targeted Intraoperative Radiotherapy (TARGIT-A) Study Design Eligibility (N = 2,232) Invasive ductal breast carcinoma Undergoing breast-conserving surgery 45 years of age TARGIT n = 1,113 Single-dose TARGIT with Intrabeam (~85% of patient population)* R EBRT n = 1,119 EBRT

4550 Gy in 15-25 fractions +/- Boost 10-16 Gy in 5-8 fractions * Plus EBRT (45-50 Gy, no boost) in patients at high risk (~15%); Pre-specified criteria (unsuspected lobular carcinoma, lymphovascular invasion, etc) Baum M et al. Proc ASCO 2010;Abstract LBA517; Vaidya JS et al. Lancet 2010;[Epub ahead of print]. Local Recurrence Rates in the Conserved Breast Local recurrence rate 95% confidence interval TARGIT n = 1,113 EBRT n = 1,119 p-value 1.2% 0.95%

0.41 0.532.71 0.392.31 * Restricted to 4 years as less than 420 patients (<20%) have follow-up beyond this point. All patients (with maximum follow-up of 10 years) are included in the analysis. Baum M et al. Proc ASCO 2010;Abstract LBA517; Vaidya JS et al. Lancet 2010;[Epub ahead of print]. Complications TARGIT n = 1,113 Any 196 (17.6%) EBRT n = 1,119 174 (15.4%) p-value

0.19 Clinically important wound complications TARGIT EBRT p-value Hematoma requiring surgical evacuation 11 (1.0%) 7 (0.6%) 0.338 Seroma requiring more than 3 aspirations 23 (2.1%) 9 (0.8%) 0.012 Infection requiring

intravenous antibiotics or surgery 20 (1.8%) 14 (1.3%) 0.292 Baum M et al. Proc ASCO 2010;Abstract LBA517; Vaidya JS et al. Lancet 2010;[Epub ahead of print]. Complications Major toxicity Skin breakdown or delayed wound healing RTOG toxicity Grade 3-4 Major toxicity TARGIT n = 1,113 EBRT n = 1,119 p-value 31 (2.8%)

21 (1.9%) 0.155 6 (0.5%) 23 (2.1%) 0.002 37 (3.3%) 44 (3.9%) 0.443 Baum M et al. Proc ASCO 2010;Abstract LBA517; Vaidya JS et al. Lancet 2010;[Epub ahead of print]. Conclusions For selected patients with early breast cancer, a single dose of radiotherapy delivered at the time of surgery by use of TARGIT should be considered as an alternative to EBRT delivered over several

weeks. Rate of local recurrence is not statistically different among TARGIT and EBRT groups at 4 years (1.2% vs 0.95%, p = 0.41) Non-inferiority established for TARGIT Frequency of any complications and major toxicity overall were similar in TARGIT group versus EBRT group. Major toxicity (3.3% vs 3.9%, p = 0.44) RTOG toxicity Grade 3 to 4 (0.5% vs 2.1%, p = 0.002) Baum M et al. Proc ASCO 2010;Abstract LBA517; Vaidya JS et al. Lancet 2010;[Epub ahead of print]. Investigator comment on the results of the TARGIT trial of intraoperative radiation therapy The real challenge of this study was that 90 percent of local recurrences after surgery with or without radiation therapy are in the index quadrant, even though 70 percent of cases have other foci outside the index quadrant. So we now believe that the out-of-theindex-quadrant foci are latent disease. We challenged conventional thinking in two ways: Using partial breast irradiation and completing treatment within 25 to 45 minutes during surgery. Local recurrence rates were low and equivalent to external beam radiation therapy (EBRT). At a median of four years, the KaplanMeier curves are superimposable, with a difference of 0.25 percent in a good-prognosis group of patients. There were no overall differences in toxicity, but in terms of RTOG radiation toxicity, there was significantly more Grade 3/4 toxicity, particularly skin complications, with EBRT. There was a specific wound complication of seroma with the intraoperative approach. Interestingly, the cosmesis is better with intraoperative radiation

therapy due to the seroma, which acts as a biological implant. We also believe there are other long-term cosmesis advantages, particularly following oncoplastic surgery, because the intraoperative approach provides perfect conformal treatment at the time of surgery. Interview with Michael Baum, MD, ChM, June 6, 2010 Investigator comment on the results of the TARGIT trial of intraoperative radiation therapy The TARGIT study randomly assigned patients to intraoperative or external beam radiation therapy. They did not observe any significant difference in outcome between the two groups, which, at least on the surface, would suggest that a targeted, more limited, less time-consuming therapy might be as effective as administering external beam radiation therapy. The problem is that the two-year follow-up is short. This is not a treatment that we should all be embracing at the moment, but it is a treatment that we should pay attention to and its a study result that we should follow. Its quite likely that in the years ahead these more targeted, localized therapies will be the way to go for some patients with breast cancer. Interview with Eric P Winer, MD, July 6, 2010

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