Intergroup Collaboration Against Sarcomas (Icas) Focus

Intergroup Collaboration Against Sarcomas (Icas) Focus

INTERGROUP COLLABORATION AGAINST SARCOMAS (ICAS) FOCUS Biologically targeted therapeutics Histology specific Facilitate Intergroup Collaboration Growth Factor Receptor Expression in Sarcomas Sarcoma EGF-R* MPNST 7/7 -- Synovial Cell* 17/25 0/2 Fibrosarcoma 8/11

-- 12/17 11/12 MFH PDGF-R** Liposarcoma -- 9/12 Leiomyosarcoma -- 3/7 *Common (70%) SSX1 translocation: Her2 21/32 Her4 12/13 JCI 105:1233 2000

* L Baker et al AACR 2002 **Can Res 50:6344 1990 INTERGROUP SARCOMA COMMITTEE HER2 and Cox-2 Expression in Synovial Sarcomas Her2/neu Cox-2 EGF-R EXPRESSION AND INHIBITION IN MPNST Intense membrane staining EGF-R inhibitors DeClue et al JCI 2000 ICAS STUDIES Metastatic Disease ICAS # Sarcoma

Target Inhibitor Prior Rx S0330 MPNST EGF-R erlotinib N S0345 DFSP PDGF-R imatinib Y S0346 Synovial

HER2* trastuzumab Y S0505 STS VEGF sorafenib Y ICAS STUDIES Metastatic Disease ICAS # Sarcoma Target S0423 Chondro

MTAP pemetrexed Y VEGF bevacizumab N imatinib N S0502 GIST S0416 (COG) GIST(<30) kit S0406 (RTOG) STS COX-2 Inhibitor celocoxib

EWS0031(COG) Ewings dose density chemo Prior Rx Y N ICAS STUDIES Primary Disease ICAS # Sarcoma Target Inhibitor Prior Rx S0344 Chondro local surgery

telomerase S0405 (COG) Synovial bcl-2 anti-sense S0404 (ACSOG) STS ACOSOG STS array/microscopy retroperitoneal XRT N N N ICAS NEW ERA 2000 MOLECULAR REDEFINITION IMPROVE PRIMARY MANAGEMENT IDENTIFY TARGETED THERAPIES

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