Director of Global Marketing - maWebCenters

Director of Global Marketing - maWebCenters

Market America World Conference February 2016 & by Dr. Steven Lamm Learn How to Defend Your Health Isotonix HEART BRAIN Isotonix MUSCLES EYES

VEINS SKIN Build mass but dont lose it! Defend Your Muscles NEW STUDY : Muscle Function / Sarcopenia 64 subjects with loss of muscle mass with age (sarcopenia) 70-78 years of age with high oxidative stress (>320 Carr U) 2 months Belcaro G. et al, in submission Pycnogenol improves muscular function

% improvement in muscular function in 8 weeks 80% 70% 71% * 60% 50% 52% * 40% 43% 38%

23% 20% 17% 10% 0% * * 30% * 42% 17% 20%

* 20% 5% -4% Pycnogenol Belcaro G. et al, in submission Controls *p<0.05 vs baseline and controls Pycnogenol decreases proteinuria* *a marker of muscular loss in urine Proteinuria [mg/day] 260.0 Control Group 244.0 240.0

220.0 200.0 180.0 160.0 140.0 * Pycnogenol 148.5 -40% 120.0 100.0 Baseline Belcaro G. et al, in submission 8 weeks *p<0.05 vs baseline and controls

Defend Your Brain Clinical Study with 77 subjects 55-70 years of age with high oxidative stress Belcaro G. et al, J Neurosurg Sci. 2015 submitted Pycnogenol improves cognitive functions % improvement of cognitive functions (VASL) after 12 months C ni og e tiv fu

n tio c n A n tte n tio l ta n e M ce n a

rm o rf pe a st u S ed in a tio n tte n y or em

m cu e e*x e tiv fu tio c n ns * od o m 60.0%

50.0% * * 40.0% 30.0% * * * 41.2% 35.2% 37.7% 33.0% 55.8%

50.9% 37.3% 20.0% 10.0% 0.0% -1.8% 1.9% 1.9% 3.8% 1.9% -9.8% -10.0% -7.1%

-20.0% Pycnogenol Belcaro G. et al, J Neurosurg Sci. 2015 submitted Controls *p<0.05 Defend Your Eyes Clinical Study with 77 subjects 9 months Aim prevention of a new retinal vein thrombosis episode Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125. Pycnogenol and retinal vein thrombosis

Pycnogenol in prevention of retinal vein thrombosis 20% 18% 16% 17.39% 15.38% 14% Controls Aspirin Pycnogenol 12% 10% 8% * 6% 3.56%

4% 2% 0% Diagnosed new RVT % in 9 months 9 months *p<0.05 Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125. Pycnogenol effect on retinal edema Pycnogenol decreases retinal edema 2.50 2.00 Controls Aspirin Pycnogenol 1.50

1.00 2.10 2 2.00 0.50 1.90 * 1.8 0.90 0.00 Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125.

*p<0.05 Pycnogenol effect on visual acuity Pycnogenol improves visual acuity 0.90 20/25 * 0.80 0.70 20/32 20/40 0.60 Controls Aspirin Pycnogenol 0.50 0.40 0.30

0.20 0.10 0.00 *p<0.05 Rodriguez, P., et al. (2015). " Panminerva Med 57(3): 121-125. Defend Your Skin Clinical Study with 20 menopausal women Aged 55-68 years, Skin type II or III Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17.

start 12 weeks effects on melanogenesis Pycnogenol start 12 weeks UVA-1 radiation 100 J/cm2 (area of 4 cm2) Treatment regimen: 75 mg oral Pycnogenol for 12 weeks Biopsies at start and at 12 weeks before and after UV radiation mRNA expression of MITF, TRP1, MART, Tyrosinase & Loricrin Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17. Pycnogenol inhibits UVA induced hyperpigmentation % increase in mRNA following UVA irradiation before and after 12 weeks Pycnogenol p=0.008 120.0%

100.0% p=0.008 80.0% p=0.014 60.0% 108.0% 40.0% -67% 20.0% 51.0% -67% 70.0% 45.0% 17.00%

0.0% -75% -51% MITF 22.00% Tyrosinase Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17. 27.00% TRP1 19.00% MART1 Pycnogenol increases gene expression of loricrin Loricrin, a major component of the cornified cell in the stratum corneum accounts for much of cornified envelope mechanical resistance.

X 2.5 P=0.017 Grether-Beck, S., et al. (2015). " Skin Pharmacol Physiol 29(1): 13-17. Pycnogenol compared to European OTC for venous health Example : Chronic Venous Insufficiency Pycnogenol vs. Ankle Swelling Resting Flux Ankle Circumference -0%

-0% Antistax Pain -2% Edema -3% Compression -6% -11% -20% -27% -48% -41%

-48% -86% *p<0.05 vs baseline, N=166, Antistax 720 mg/day, Pycnogenol 100mg/day Belcaro, G. (2015). " International Journal of Angiology. Pycnogenol more effective than Antistax Signs and symptoms of CVI Edema Capillary filtration Blood flow Microcirculation Oxidative stress And more Belcaro, G. (2015). " International Journal of Angiology. Isotonix Helps Defend Your Health Defend Your Health Thank you HORPHAG RESEARCH

PO Box 80 Avenue Louis-Casa 71 CH-1216 Cointrin / GENEVA Switzerland Tel +41 (0)22 710 26 26 Fax +41 (0)22 710 26 00

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