Aldosterone - Santa Monica College

Aldosterone - Santa Monica College

Aldosterone Deanna Page SYNTHESIS Aldosterone is synthesized by the cells of the Zona Glomerulosa of the Adrenal Cortex in the Adrenal Gland, located above the Kidneys.

STRUCTURE C21H28O5 A steroid hormone, class of corticosteroids (steroid produced in

the adrenal cortex), main mineralocorticoid (class of corticosteroid, produced in the adrenal cortex) REGUALTION AND ACTION Synthesis of aldosterone is stimulated by

elevated levels of blood potassium Angiotensin II, a product of the renin-angiotensin-aldosterone system. Directly stimulates the reabsorption of sodium and the excretion of potassium by principal cells of the distal tubule and the collecting duct. indirectly influences blood pressure, blood volume, and water retention.

Renin Angiotensin Aldosterone Pathway 1. Create Na+/K+ pump to drive K+ ions into the principal cell of collective duct. 2. Creates K+ channels on the apical surface of the principal cell to allow K+ to flow through

passive transport to the urine 3. Creates Na+ channels on the apical surface of the principal cell to allow Na+ from the urine into the principal cell, then through the Na+/K+ pump into the blood. a. High concentration of Na+ in blood causes osmosis to occur, so water from the urine will come into the blood b. Increased stroke volume = Increased blood pressure Goal: Bring in Na+ from urine into the bloodstream through different channels

How do leftover protons escape cell? Proton pump Sodium proton pump H+ Potassium proton pump

H+ Na+ H2O + CO2 H2CO3 H+ + HCO3- H+ + HCO3Stimulates secretion of H+, rremoves excess protons from blood H+

K+ Goal: Get rid of leftover protons in alpha intercalated cell through pumps that also power the aldosterone pathway to increase blood pressure Juxtaglomerular (JG) cells = primary site of renin storage and release reduction in afferent arteriole pressure release of renin from the JG cells

increased pressure inhibits renin release. Specialized cells (macula densa) = senses the concentration of sodium and chloride ions in the tubular fluid NaCl is elevated in the tubular fluid inhibits renin release reduction in tubular NaCl stimulates renin release by the JG cells MINERALCORTICOID RECEPTOR ALDOSTERONE RECEPTOR

It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. LOW LEVELS VS HIGH LEVELS Low Levels of Aldosterone: --dehydration, low blood pressure, a low blood sodium level, and a high potassium level, high pulse --symptoms of fatigue and often salt-craving, cognitive fuzziness, dizziness or lightheadedness on standing, or

palpitations High Levels of Aldosterone: --increases reabsorption of sodium and loss of potassium by the kidneys, low potassium level, high blood pressure symptoms include headache and muscle weakness, especially if potassium levels are very low

-- THE END

Recently Viewed Presentations

  • India The Golden Ages India Empires of India

    India The Golden Ages India Empires of India

    Ruled according to the Hindu-Buddhist doctrine of dharma. follow moral law. India remained divided into small kingdoms for about 400 years. Then around AD 320, the Gupta dynasty took over northern India. Under the Gupta, northern India was reunited, Indian...
  • Host defense and the Innate Immune System Figure

    Host defense and the Innate Immune System Figure

    BLP mediates both apoptosis and NF-KappaB activation through TLR2. TLR2 is also responsible for the recognition of the Yeast cell-wall particle Zymosan. Zymosan acts through the CD14 receptor to influence TLR2. TLR2 signals the production of TNF (Tumour Necrosis Factor),...
  • Chapter 1

    Chapter 1

    Hortatory techniques Encourage people to comply with policy by appealing to their better instincts. "Just Say No." Policy Evaluation The process of determining whether a course of action is achieving its intended goals.
  • artmasterpiecersf.weebly.com

    artmasterpiecersf.weebly.com

    Unit 1: A Color Time with Rhythm and Rhyme. Diego Rivera, Flower Day (1925) Helen Frankenthaler, Mountains and Sea (1952) Henri Matisse, The Dessert: Harmony in Red
  • Unit 2: Research Methods: Thinking Critically with ...

    Unit 2: Research Methods: Thinking Critically with ...

    Overconfidence Together with hindsight bias, can lead to overestimate our intuition "There is not reason for anyone to have a computer in their home."
  • In Search Of Excellence In Project Management

    In Search Of Excellence In Project Management

    Times New Roman Monotype Sorts Book Antiqua Arial Zurich BT diamondc ENGR 281 Engineering Scholars Program Project Management Overview K. F. Reinschmidt J. L. Frank / Marathon Ashland Petroleum LLC Chair in Engineering Project Management [email protected] Slide 2 Slide 3...
  • Zero Waste Master Plan - Cambridge

    Zero Waste Master Plan - Cambridge

    Waste Reduction & Diversion . Recycle Right Campaign. Small Business Recycling Pilot (Nov 2018 launch) Mattress Recycling. Examine existing recycling center, 2020. Textile recycling strategy, 2020/2021. Continue support for food waste reduction, sharing libraries, reuse events. Potential to reduce trash...
  • Chauncy Awards Monday 20th Friday 24th January YEAR SEVEN ...

    Chauncy Awards Monday 20th Friday 24th January YEAR SEVEN ...

    YEAR SEVEN BRONZE AWARDS YEAR EIGHT BRONZE AWARDS YEAR NINE BRONZE AWARDS YEAR TEN BRONZE AWARDS YEAR ELEVEN BRONZE AWARDS This academic year None this week YEAR ...